5557736313
contacto@zaragoza.unam.mx

CITOGENÉTICA Y MUTAGÉNESIS

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Á R E A    D E    I N T E R É S

Citogenética, estudia la estructura, función y evolución de los cromosomas, vehículos de la herencia que residen en el núcleo de la célula. Mutación cualquier cambio detectable y heredable del ADN, que se transmite a las células hijas e incluso a la generación siguiente. Mutagénesis, génesis u origen de las mutaciones.
Nuestra área de interés se centra por tanto, en el estudio de los mecanismos de inducción de daño e inestabilidad genómica de individuos expuestos a xenobióticos, ya sea por tratamiento médico, laboral o accidental. Toxicología celular, bioquímica y molecular, son competencia de nuestros estudios. Así como realizar investigación original que profundice sobre los mecanismo de acción, y la relación con el desarrollo o manifestación de enfermedades crónico-degenerativas, y sobre la función reproductiva en el hombre.
De tal forma que monitorear y cuantificar mediante biomarcadores de exposición y efecto, daño cromosómico (ADN) de células somáticas y gaméticas de individuos expuestos, o en modelos biológicos, tanto in vivo como in vitro, son nuestro objetivo. Mediante diferentes bioensayos como Micronúcleos con bloqueo de la citocinesis (MNBC) y en células exfoliadas orales (MNxl), Intercambio de cromátidas hermanas (ICHs) y electroforesis unicelular alcalina (EUA), entre otros, se cumplen objetivos.
O B J E T I V O S
Estudiar los mecanismos de inducción de daño toxicológico y de inestabilidad genómica tanto en células somáticas como gaméticas de individuos expuestos a xenobióticos, mediante diferentes ensayos in vitro e in vivo.

Elia-Roldán-ReyesElia-Roldán-ReyesElia-Roldán-Reyes

P R O D U C C I Ó N    C I E N T Í F I C A

RESPONSABLE

Dra. Elia Roldán Reyes
Profesor de Carrera Titular “A” de TC (definitivo)
Teléfono: 56230700 ext. 39184
Correo electrónico:mailto:eliar@unam.mx

UBICACIÓN

Laboratorio 2 planta alta, UMIEZ-CII. Batalla 5 de mayo S/N esq. Fuerte Loreto, Col. Ejército de Oriente, Iztapalapa, Ciudad de México. CP09230.
I N T E G R A N T E S:
▪ M. en C. Soledad Guevara Chávez
▪ Biol. Cynthia Briseño Gómez
▪ Dra. Ma. Lilia Alicia Alcantar Zavala

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