miércoles, abril 30, 2025
  1. Inicio
  2. /
  3. Investigación
  4. /
  5. Líneas de Investigación
  6. /
  7. Enfermedades crónicas y neoplásicas:...

LÍNEA DE INVESTIGACIÓN EN ENFERMEDADES CRÓNICAS Y NEOPLÁSICAS: CARACTERIZACIÓN DE BIOMARCADORES Y BLANCOS TERAPÉUTICOS

RESPONSABLE
Dr. Octavio Daniel Reyes Hernández
Profesor de Carrera Titular “B” Tiempo Completo

Teléfonos: 55 1706 4638 / 55 5623 0500 Ext. 83202
Correo electrónico: octavio.reyes@zaragoza.unam.mx

LI-FESZ-711024

UBICACIÓN
Laboratorio de Farmacogenética (L-1, 2° Piso), UMIEZ. FES Zaragoza, Campus II. Batalla 5 de mayo S/N, Esq. Fuerte de Loreto, E. de Oriente, Iztapalapa, Ciudad de México, México. C.P. 09230

INTEGRANTES
  • Dra. Gabriela Figueroa González – FES-Z
  • Dra. Teresita Padilla Benavides – WU
  • Dr. Hernán Cortés Callejas – INRLGII
  • Dr. Gerardo Leyva Gómez – FQ-UNAM
  • Biol. Gareth Omar Rostro Alonso – FES-Z
  • Biol. Alejandro Israel Castillo Montoya – FES-Z
PRODUCCIÓN CIENTÍFICA
    1. Padilla-Mendoza, J. R., Contis-Montes de Oca, A., Rodríguez, M. A., LópezCasamichana, M., Bolaños, J., Quintas-Granados, L. I., Reyes-Hernández, O. D., Fragozo-Sandoval, F., Reséndiz-Albor, A. A., Arellano-Gutiérrez, C. V., & LópezReyes, I. (2020). Protein Phosphorylation in Serine Residues Correlates with Progression from Precancerous Lesions to Cervical Cancer in Mexican Patients. BioMed research international, 2020, 5058928. https://doi.org/10.1155/2020/5058928
    2. González-Del Carmen, M., Montaño, S., Reyes-Hernández, O. D., VizcaínoDorado, P. A., Leyva-García, N., Morales-Morfín, J. C., Diaz-Beltran, W., QuintoSantiago, E., Cariño-Calvo, L., Magaña, J. J., Leyva-Gómez, G., & Cortés, H. (2020). High prevalence of autosomal recessive congenital ichthyosis in a Mexican population caused by a new mutation in the TGM1 gene: epidemiological evidence of a founder effect. International journal of dermatology, 59(8), 969–977. https://doi.org/10.1111/ijd.14952
    3. Cortes, H., Caballero-Florán, I. H., Mendoza-Muñoz, N., Córdova-Villanueva, E. N., Escutia-Guadarrama, L., Figueroa-González, G., Reyes-Hernández, O. D., González-Del Carmen, M., Varela-Cardoso, M., Magaña, J. J., Florán, B., Del Prado-Audelo, M. L., & Leyva-Gómez, G. (2020). Hyaluronic acid in wound dressings. Cellular and molecular biology (Noisy-le-Grand, France), 66(4), 191–198.
    4. Cortes, H., Caballero-Florán, I. H., Mendoza-Muñoz, N., EscutiaGuadarrama, L., Figueroa-González, G., Reyes-Hernández, O. D., González-Del Carmen, M., Varela-Cardoso, M., González-Torres, M., Florán, B., Del PradoAudelo, M. L., & Leyva-Gómez, G. (2020). Xanthan gum in drug release. Cellular and molecular biology (Noisy-le-Grand, France), 66(4), 199–207.
    5. Cortés, H., Alcalá-Alcalá, S., Caballero-Florán, I. H., Bernal-Chávez, S. A., Ávalos-Fuentes, A., González-Torres, M., González-Del Carmen, M., FigueroaGonzález, G., Reyes-Hernández, O. D., Floran, B., Del Prado-Audelo, M. L., & Leyva-Gómez, G. (2020). A Reevaluation of Chitosan-Decorated Nanoparticles to Cross the Blood-Brain Barrier. Membranes, 10(9), 212. https://doi.org/10.3390/membranes10090212
    6. Padilla-Mendoza, J. R., Gómez-López, L. A., López-Casamichana, M., Azuara-Liceaga, E. I., Cortés-Malagón, E. M., López-Cánovas, L., ReyesHernández, O. D., Rodríguez, M. A., Bonilla-Delgado, J., & López-Reyes, I. (2020). Human Papillomavirus Coinfection in the Cervical Intraepithelial Lesions and Cancer of Mexican Patients. BioMed research international, 2020, 4542320. https://doi.org/10.1155/2020/4542320
    7. Cortés, H., Rojas-Márquez, M., Reyes-Hernández, O. D., Morales-Morfín, J. C., Guapillo-Vargas, M. R. B., Varela-Cardoso, M., Magaña, J. J., LeyvaGómez, G., & González-Del Carmen, M. (2021). Increased risk of depression and impairment in quality of life in patients with lamellar ichthyosis. Dermatologic therapy, 34(1), e14628. https://doi.org/10.1111/dth.14628
    8. Figueroa-González, G., Arellano-Gutiérrez, C. V., Cortés, H., Leyva-Gómez, G., Carmen, M. G., Bustamante-Montes, L. P., Rodríguez-Morales, M., LópezReyes, I., Alcaraz-Estrada, S. L., Sandoval-Basilio, J., Quintas-Granados, L. I., & Reyes-Hernández, O. D. (2020). Breast cancer-related single-nucleotide polymorphism and their risk contribution in Mexican women. Journal of cancer research and therapeutics, 16(6), 1279–1286. https://doi.org/10.4103/jcrt.JCRT_14_20
    9. Cortés, H., Reyes-Hernández, O. D., Alcalá-Alcalá, S., Bernal-Chávez, S. A., Caballero-Florán, I. H., González-Torres, M., Sharifi-Rad, J., González-Del Carmen, M., Figueroa-González, G., & Leyva-Gómez, G. (2021). Repurposing of Drug Candidates for Treatment of Skin Cancer. Frontiers in oncology, 10, 605714. https://doi.org/10.3389/fonc.2020.605714
    10. Bernal-Chávez, S. A., Del Prado-Audelo, M. L., Caballero-Florán, I. H., Giraldo-Gomez, D. M., Figueroa-Gonzalez, G., Reyes-Hernandez, O. D., González-Del Carmen, M., González-Torres, M., Cortés, H., & Leyva-Gómez, G. (2021). Insights into Terminal Sterilization Processes of Nanoparticles for Biomedical Applications. Molecules (Basel, Switzerland), 26(7), 2068. https://doi.org/10.3390/molecules26072068
    11. Cortés, H., Rojas-Márquez, M., Del Prado-Audelo, M. L., ReyesHernández, O. D., González-Del Carmen, M., & Leyva-Gómez, G. (2022). Alterations in mental health and quality of life in patients with skin disorders: a narrative review. International journal of dermatology, 61(7), 783–791. https://doi.org/10.1111/ijd.15852
    12. Cortés, H., Reyes-Hernández, O. D., Gonzalez-Torres, M., VizcainoDorado, P. A., Del Prado-Audelo, M. L., Alcalá-Alcalá, S., Sharifi-Rad, J., Figueroa-González, G., González-Del Carmen, M., Florán, B. N., & Leyva-Gómez, G. (2021). Curcumin for parkinson´s disease: potential therapeutic effects, molecular mechanisms, and nanoformulations to enhance its efficacy. Cellular and molecular biology (Noisy-le-Grand, France), 67(1), 101–105. https://doi.org/10.14715/cmb/2021.67.1.15
    13. Leyva-Gómez, G., González-Torres, M., Alcalá-Alcalá, S., Bernal-Chávez, S. A., Morales-Morfin, J. C., González-Del Carmen, M., Sharifi-Rad, J., FigueroaGonzález, G., Reyes-Hernández, O. D., Del Prado-Audelo, M. A. L., & Cortés, H. (2021). Development of films from natural sources for infections during wound healing. Cellular and molecular biology (Noisy-le-Grand, France), 67(1), 96–100. https://doi.org/10.14715/cmb/2021.67.1.14
    14. Robles-Kanafany, C. M., Del Prado-Audelo, M. A. L., González-Torres, M., Giraldo-Gomez, D. M., Caballero-Florán, I. H., González-Del Carmen, M., SharifiRad, J., Figueroa-González, G., Reyes-Hernández, O. D., Cortés, H., & LeyvaGómez, G. (2021). Development of a guar gum film with lysine clonixinate for periodontal treatments. Cellular and molecular biology (Noisy-le-Grand, France), 67(1), 89–95. https://doi.org/10.14715/cmb/2021.67.1.13
    15. Villar-Padilla, A., Del Prado-Audelo, M. A. L., González-Torres, M., GiraldoGomez, D. M., Caballero-Florán, I. H., González-Del Carmen, M., Sharifi-Rad, J., Figueroa-González, G., Reyes-Hernández, O. D., Cortés, H., & Leyva-Gómez, G. (2021). Development of a xanthan gum film for the possible treatment of vaginal infections. Cellular and molecular biology (Noisy-le-Grand, France), 67(1), 80–88. https://doi.org/10.14715/cmb/2021.67.1.12
    16. López-Huante, T., Del Prado-Audelo, M. A. L., Caballero-Florán, I. H., Reyes-Hernández, O. D., Figueroa-González, G., González-Del Carmen, M., Giraldo-Gomez, D. M., Sharifi-Rad, J., González-Torres, M., Cortes, H., & LeyvaGómez, G. (2021). Physicochemical and biological characterization of a xanthan gum-polyvinylpyrrolidone hydrogel obtained by gamma irradiation. Cellular and molecular biology (Noisy-le-Grand, France), 67(1), 73–79. https://doi.org/10.14715/cmb/2021.67.1.11
    17. Del Prado-Audelo, M. A. L., Gómez-Zaldivar, F. J., Pérez-Dí Az, M., Sánchez-Sánchez, R., González-Torres, M., González-Del Carmen, M., FigueroaGonzález, G., Sharifi-Rad, J., Reyes-Hernández, O. D., Cortés, H., & LeyvaGómez, G. (2021). Radiation-induced graft polymerization of elastin onto polyvinylpyrrolidone as a possible wound dressing. Cellular and molecular biology (Noisy-le-Grand, France), 67(1), 64–72. https://doi.org/10.14715/cmb/2021.67.1.10
    18. Godoy-Alvarez, F. K., González-Torres, M., Giraldo-Gomez, D. M., Sánchez-Sánchez, R., Pérez-Dí Az, M. A., González-Del Carmen, M., FigueroaGonzález, G., Reyes-Hernández, O. D., Sharifi-Rad, J., Cortés, H., Del PradoAudelo, M. A. L., & Leyva-Gómez, G. (2021). Synthesis by gamma irradiation of hyaluronic acid-polyvinyl alcohol hydrogel for biomedical applications. Cellular and molecular biology (Noisy-le-Grand, France), 67(1), 58–63. https://doi.org/10.14715/cmb/2021.67.1.9
    19. Quintas-Granados, L. I., Cortés, H., Carmen, M. G., Leyva-Gómez, G., Bustamante-Montes, L. P., Rodríguez-Morales, M., Villegas-Vazquez, E. Y., López-Reyes, I., Alcaraz-Estrada, S. L., Sandoval-Basilio, J., Soto-Reyes, E., Sharifi-Rad, J., Figueroa-González, G., & Reyes-Hernández, O. D. (2021). The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis. Cancer cell international, 21(1), 649. https://doi.org/10.1186/s12935-021-02343-7
    20. Arellano-Gutiérrez, C. V., Quintas-Granados, L. I., Cortés, H., González Del Carmen, M., Leyva-Gómez, G., Bustamante-Montes, L. P., Rodríguez-Morales, M., López-Reyes, I., Padilla-Mendoza, J. R., Rodríguez-Páez, L., FigueroaGonzález, G., & Reyes-Hernández, O. D. (2022). Indole-3-Carbinol, a Phytochemical Aryl Hydrocarbon Receptor-Ligand, Induces the mRNA Overexpression of UBE2L3 and Cell Proliferation Arrest. Current issues in molecular biology, 44(5), 2054–2068. https://doi.org/10.3390/cimb44050139
    21. Villegas-Vázquez, E. Y., Quintas-Granados, L. I., Cortés, H., González-Del Carmen, M., Leyva-Gómez, G., Rodríguez-Morales, M., Bustamante-Montes, L. P., Silva-Adaya, D., Pérez-Plasencia, C., Jacobo-Herrera, N., Reyes-Hernández, O. D., & Figueroa-González, G. (2023). Lithium: A Promising Anticancer Agent. Life (Basel, Switzerland), 13(2), 537. https://doi.org/10.3390/life13020537
    22. Hernández-Parra, H., Reyes-Hernández, O. D., Figueroa-González, G., González-Del Carmen, M., González-Torres, M., Peña-Corona, S. I., Florán, B., Cortés, H., & Leyva-Gómez, G. (2023). Alteration of the blood-brain barrier by COVID-19 and its implication in the permeation of drugs into the brain. Frontiers in cellular neuroscience, 17, 1125109. https://doi.org/10.3389/fncel.2023.1125109
    23. Cortes, H., Hernández-Parra, H., Bernal-Chávez, S. A., Caballero-Florán, I. H., Aguilar-Vázquez, R., Del Prado-Audelo, M. L., González-Torres, M., ReyesHernández, O. D., Figueroa-González, G., & Leyva-Gómez, G. (2023). Current Status of the Therapeutic Approach for Dysmenorrhea. Cellular and molecular biology (Noisy-le-Grand, France), 69(3), 52–63. https://doi.org/10.14715/cmb/2023.69.3.7
    24. Baez-Gonzalez, A. S., Carrazco-Carrillo, J. A., Figueroa-Gonzalez, G., Quintas-Granados, L. I., Padilla-Benavides, T., & Reyes-Hernandez, O. D. (2023). Functional effect of indole-3 carbinol in the viability and invasive properties of cultured cancer cells. Biochemistry and biophysics reports, 35, 101492. https://doi.org/10.1016/j.bbrep.2023.101492
    25. Cortés, H., Cariño-Calvo, L., Reyes-Hernández, O. D., Rojas-Márquez, M., Magaña, J. J., Vizcaino-Dorado, P. A., Villegas-Vazquez, E. Y., QuintasGranados, L. I., Jiménez-Islas, E., Cortés-Mollinedo, V. A., Leyva-Gómez, G., & González-Del Carmen, M. (2023). High Levels of Anxiety, Depression, Risk of Suicide, and Implications for Treatment in Patients with Lamellar Ichthyosis. Healthcare (Basel, Switzerland), 11(14), 2071. https://doi.org/10.3390/healthcare11142071
    26. Corona-Trejo, A., Gonsebatt, M. E., Trejo-Solis, C., Campos-Peña, V., Quintas-Granados, L. I., Villegas-Vázquez, E. Y., Reyes-Hernández, O., Hernández-Abad, V. J., Figueroa-González, G., & Silva-Adaya, D. (2023). Transsulfuration pathway: a targeting neuromodulator in Parkinson’s disease. Reviews in the neurosciences, 34(8), 915–932. https://doi.org/10.1515/revneuro2023-0039
    27. Reyes-Hernández, O. D., Figueroa-González, G., Quintas-Granados, L. I., Gutiérrez-Ruíz, S. C., Hernández-Parra, H., Romero-Montero, A., Del PradoAudelo, M. L., Bernal-Chavez, S. A., Cortés, H., Peña-Corona, S. I., Kiyekbayeva, L., Ateşşahin, D. A., Goloshvili, T., Leyva-Gómez, G., & Sharifi-Rad, J. (2023). 3,3’Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways. Cancer cell international, 23(1), 180. https://doi.org/10.1186/s12935-023-03031-4
    28. Reyes-Hernández, O. D., Figueroa-González, G., Quintas-Granados, L. I., Hernández-Parra, H., Peña-Corona, S. I., Cortés, H., Kipchakbayeva, A., Mukazhanova, Z., Habtemariam, S., Leyva-Gómez, G., Büsselberg, D., & SharifiRad, J. (2024). New insights into the anticancer therapeutic potential of icaritin and its synthetic derivatives. Drug development research, 85(2), e22175. https://doi.org/10.1002/ddr.22175
    29. Figueroa-González, G., Quintas-Granados, L. I., Reyes-Hernández, O. D., Caballero-Florán, I. H., Peña-Corona, S. I., Cortés, H., Leyva-Gómez, G., Habtemariam, S., & Sharifi-Rad, J. (2024). Review of the anticancer properties of 6-shogaol: Mechanisms of action in cancer cells and future research opportunities. Food science & nutrition, 12(7), 4513–4533. https://doi.org/10.1002/fsn3.4129
    30. Rostro-Alonso, G. O., Castillo-Montoya, A. I., García-Acosta, J. C., Aguilar-Llanos, E. F., Quintas-Granados, L. I., Villegas-Vazquez, E. Y., García-Aguilar, R., Porras-Vázquez, S. A., Bustamante-Montes, L. P., Alvarado-Sansininea, J. J., Jiménez-Estrada, M., Cariño-Calvo, L., Carmen, M. G., Cortés, H., Leyva-Gómez, G., Figueroa-González, G., & Reyes-Hernández, O. D. (2024). Cacalol Acetate as Anticancer Agent: Antiproliferative, Pro-Apoptotic, Cytostatic, and Anti-Migratory Effects. Current issues in molecular biology, 46(9), 9298–9311. https://doi.org/10.3390/cimb46090550
    31. García-Acosta, J. C., Castillo-Montoya, A. I., Rostro-Alonso, G. O., Villegas-Vázquez, E. Y., Quintas-Granados, L. I., Sánchez-Sánchez, L., López-Muñóz, H., Cariño-Calvo, L., López-Reyes, I., Bustamante-Montes, L. P., Leyva-Gómez, G., Cortés, H., Jacobo-Herrera, N. J., García-Aguilar, R., Reyes-Hernández, O. D., & Figueroa-González, G. (2024). Unrevealing Lithium Repositioning in the Hallmarks of Cancer: Effects of Lithium Salts (LiCl and Li2CO3) in an In Vitro Cervical Cancer Model. Molecules (Basel, Switzerland), 29(18), 4476. https://doi.org/10.3390/molecules29184476
    32. Villegas-Vazquez, E. Y., Marín-Carrasco, F. P., Reyes-Hernández, O. D., Báez-González, A. S., Bustamante-Montes, L. P., Padilla-Benavides, T., Quintas-Granados, L. I., & Figueroa-González, G. (2025). Revolutionizing ovarian cancer therapy by drug repositioning for accelerated and cost-effective treatments. Frontiers in oncology, 14, 1514120. https://doi.org/10.3389/fonc.2024.1514120