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LÍNEA DE INVESTIGACIÓN EN REGULACIÓN DE LA EXPRESIÓN GENÉTICA, PROCESOS EPIGENÉTICOS Y MECANISMOS CELULARES ASOCIADOS A LA RESPUESTA A FÁRMACOS: ESTUDIO DEL DESARROLLO DE PATOLOGÍAS EN SISTEMAS EUCARIOTAS

RESPONSABLE
Dra. Gabriela Figueroa González
Prof. de Carrera Asociado “C” Tiempo Completo

Teléfono: 55 3900 5899 / 55 5623 0500 Ext. 83203
Correo electrónico: gabriela.figueroa@zaragoza.unam.mx

LI-FESZ-650622

UBICACIÓN
FES Zaragoza, Campus II, Unidad Multidisciplinaria de Investigación Experimental Zaragoza, Laboratorio 1, Segundo Piso. Laboratorio de Farmacogenética. Batalla 5 de mayo S/N, Esq. Fuerte de Loreto, Col. Ejército de Oriente, Iztapalapa, Ciudad de México, México. CP09230.

INTEGRANTES

• Dr. Octavio Daniel Reyes Hernández – FES-Z
• Dr. Edgar Yebrán Villegas Vázquez – FES-Z
• Dra. Nadia Judith Jacobo Herrera – INCMNSZ
• Dr. Gerardo Leyva Gómez – FQ-UNAM
• Pasante de Biología-FC: Alejandro Israel Castillo Montoya
• Pasante de Biología FES-Z: Gareth Omar Rostro Alonso
• Pasante de Biología FES-Z: Juan Carlos García Acosta
• Pasante de QFB FES-Z: Evelin Marlene Cedillo Belmont

PRODUCCIÓN CIENTÍFICA
  1. Lithium: A Promising Anticancer Agent. Villegas-Vázquez EY, Quintas-Granados LI, Cortés H, González-Del Carmen M, Leyva-Gómez G, Rodríguez-Morales M, Bustamante-Montes LP, Silva Adaya D, Pérez-Plasencia C, Jacobo-Herrera N, Reyes-Hernández OD, Figueroa-González G. Life (Basel). 2023 Feb 15; 13(2):537. https://doi.org/10.3390/life13020537
  2. Transsulfuration pathway: a targeting neuromodulator in Parkinson’s disease. Corona-Trejo A, Gonsebatt ME, Trejo-Solis C, Campos-Peña V, Quintas- Granados LI, Villegas-Vázquez EY, Daniel Reyes-Hernández O, Hernández- Abad VJ, Figueroa-González G, Silva-Adaya D. Rev Neurosci.2023 Jul 7. https://doi.org/10.1515/revneuro-2023-0039. Online ahead of print
  3. Functional effect of indole-3 carbinol in the viability and invasive properties of cultured cancer cells. Baez-Gonzalez AS, Carrazco-Carrillo JA, Figueroa-Gonzalez G, Quintas-Granados LI, Padilla Benavides T, Reyes-Hernandez OD. Biochem Biophys Rep. 2023 Jun 1;35:101492. . https://doi.org/10.1016/j.bbrep.2023.101492. eCollection 2023 Sep
  4. Current Status of the Therapeutic Approach for Dysmenorrhea. Cortes H, Hernández-Parra H, Bernal-Chávez SA, Caballero-Florán IH, Aguilar-Vázquez R, Del Prado-Audelo ML, González-Torres M, Reyes-Hernández OD, Figueroa- González G, Leyva-Gómez G. Cell Mol Biol (Noisy-le-grand). 2023 Mar 31; 69(3):52-63. http://dx.doi.org/10.14715/cmb/2023.69.3.7
  5. Alteration of the blood-brain barrier by COVID-19 and its implication in the permeation of drugs into the brain. Hernández-Parra H, Reyes-Hernández OD, Figueroa-González G, González-Del Carmen M, González-Torres M, Peña- Corona SI, Florán B, Cortés H, Leyva-Gómez G. Front Cell Neurosci. 2023 Mar14; 17:1125109. https://doi.org/10.3389/fncel.2023.1125109. eCollection 2023.
  6. Indole-3-Carbinol, a Phytochemical Aryl Hydrocarbon Receptor-Ligand, Induces the mRNA Overexpression of UBE2L3 and Cell Proliferation Arrest. Arellano- Gutiérrez CV, Quintas-Granados LI, Cortés H, González Del Carmen M, Leyva- Gómez G, Bustamante-Montes LP, Rodríguez-Morales M, López-Reyes I, Padilla-Mendoza JR, Rodríguez-Páez L, Figueroa-González G, ReyesHernández OD. Curr Issues Mol Biol. 2022 May 8; 44(5):2054-2068. https://doi.org/10.3390/cimb44050139.
  7. LKB-1 Expression and High-Risk Histopathology are Independent Prognostic Factors for Patients with Oral Cavity Carcinoma. Carrillo JF, Cruz-Romero C, Avilés-Salas A, Carrillo LC, Ramírez-Ortega MC, Herrera-Goepfert R, Vázquez- Romo R, Figueroa-González G, Altamirano-García JI, Oñate-Ocaña LF. Ann Surg Oncol. 2022 Mar 23. https://doi.org/10.1245/s10434-022-11544-x
  8. ASO Author Reflections: The Pursuit of Prognostic Factors to Fine-Tune Treatment Decisions in Patients with Oral Cavity Carcinoma. Carrillo JF, Avilés- Salas A, Herrera-Goepfert R, Figueroa-González G, Oñate-Ocaña LF. Ann Surg Oncol. 2022 Mar 22. https://doi.org/10.1245/s10434-022-11598-x
  9. The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis. Quintas-Granados LI, Cortés H, Carmen MG, Leyva-Gómez G, Bustamante-Montes LP, Rodríguez- Morales M, Villegas-Vazquez EY, López-Reyes I, Alcaraz-Estrada SL, Sandoval- Basilio J, Soto-Reyes E, Sharifi-Rad J, Figueroa-González G, Reyes-Hernández OD. Cancer Cell Int. 2021 Dec 4; 21(1):649. https://doi.org/10.1186/s12935-021-02343-7.
  10. Synthesis by gamma irradiation of hyaluronic acid-polyvinyl alcohol hydrogel for biomedical applications. Godoy-Alvarez FK, González-Torres M, Giraldo-Gomez DM, Sánchez-Sánchez R, Pérez-Dí Az MA, González-Del Carmen M, Figueroa- González G, Reyes-Hernández OD, Sharifi-Rad J, Cortés H, Del Prado-Audelo MAL, Leyva-Gómez G. Cell Mol Biol (Noisy-le-grand). 2021 Jan 31; 67(1):58-63. http://dx.doi.org/10.14715/cmb/2021.67.1.9
  11. Radiation-induced graft polymerization of elastin onto polyvinylpyrrolidone as a possible wound dressing. Del Prado-Audelo MAL, Gómez-Zaldivar FJ, Pérez-Dí Az M, Sánchez-Sánchez R, González Torres M, González-Del Carmen M, Figueroa-González G, Sharifi-Rad J, Reyes-Hernández OD, Cortés H, Leyva- Gómez G. Cell Mol Biol (Noisy-le-grand). 2021 Jan 31; 67(1):64-72. http://dx.doi.org/10.14715/cmb/2021.67.1.10
  12. Physicochemical and biological characterization of a xanthan gumpolyvinylpyrrolidone hydrogel obtained by gamma irradiation. López-Huante T, Del Prado-Audelo MAL, Caballero-Florán IH, Reyes-Hernández OD, Figueroa- González G, González-Del Carmen M, Giraldo-Gomez DM, Sharifi-Rad J, González-Torres M, Cortes H, Leyva-Gómez G. https://doi.org/10.14715/cmb/2021.67.1.11
  13. Development of a xanthan gum film for the possible treatment of vaginal infections. Villar-Padilla A, Del Prado-Audelo MAL, González-Torres M, Giraldo- Gomez DM, Caballero-Florán IH, González-Del Carmen M, Sharifi-Rad J, Figueroa-González G, Reyes-Hernández OD, Cortés H, Leyva-Gómez G. Cell Mol Biol (Noisy-le-grand). 2021 Jan 31; 67(1):80-88. https://doi.org/10.14715/cmb/2021.67.1.12.
  14. Development of a guar gum film with lysine clonixinate for periodontal treatments. Robles Kanafany CM, Del Prado-Audelo MAL, González-Torres M, Giraldo-Gomez DM, Caballero-Florán IH, González-Del Carmen M, Sharifi-Rad J, Figueroa-González G, Reyes-Hernández OD, Cortés H, Leyva-Gómez G. Cell Mol Biol (Noisy-le-grand). 2021 Jan 31; 67(1):89-95. https://doi.org/10.14715/cmb/2021.67.1.13.
  15. Development of films from natural sources for infections during wound healing.Leyva-Gómez G, González-Torres M, Alcalá-Alcalá S, Bernal-Chávez SA, Morales-Morfin JC, González-Del Carmen M, Sharifi-Rad J, Figueroa-González G, Reyes-Hernández OD, Del Prado-Audelo MAL, Cortés H. Cell Mol Biol (Noisy-le-grand). 2021 Jan 31; 67(1):96-100. https://doi.org/10.14715/cmb/2021.67.1.14.
  16. Curcumin for parkinson´s disease: potential therapeutic effects, molecular mechanisms, and nanoformulations to enhance its efficacy. Cortés H, Reyes- Hernández OD, Gonzalez-Torres M, Vizcaino-Dorado PA, Del Prado-Audelo ML, Alcalá-Alcalá S, Sharifi-Rad J, Figueroa-González G, González-Del Carmen M, Florán BN, Leyva-Gómez G. Cell Mol Biol (Noisy-le-grand). 2021 Jan 31; 67(1):101-105. https://doi.org/10.14715/cmb/2021.67.1.15.
  17. Insights into Terminal Sterilization Processes of Nanoparticles for Biomedical Applications. Bernal-Chávez SA, Del Prado-Audelo ML, Caballero-Florán IH, Giraldo-Gomez DM, Figueroa-Gonzalez G, Reyes-Hernandez OD, González-Del Carmen M, González-Torres M, Cortés H, Leyva-Gómez G. Molecules. 2021 Apr 3; 26(7):2068. https://doi.org/10.3390/molecules26072068.
  18. Repurposing of Drug Candidates for Treatment of Skin Cancer. Cortés H, Reyes- Hernández OD, Alcalá-Alcalá S, Bernal-Chávez SA, Caballero-Florán IH, González-Torres M, Sharifi-Rad J, González-Del Carmen M, Figueroa-González G, Leyva-Gómez G. Front Oncol. 2021 Jan 8; 10:605714. https://doi.org/10.3389/fonc.2020.605714. eCollection 2020.
  19. Breast cancer-related single-nucleotide polymorphism and their risk contribution in Mexican women. Figueroa-González G, Arellano-Gutiérrez CV, Cortés H, Leyva-Gómez G, Carmen MG, Bustamante-Montes LP, Rodríguez-Morales M, López-Reyes I, Alcaraz-Estrada SL, Sandoval-Basilio J, Quintas-Granados LI, Reyes-Hernández OD. J Cancer Res Ther. 2020 Oct-Dec; 16(6):1279-1286. http://dx.doi.org/10.4103/jcrt.jcrt_14_20
  20. Negative Regulation of Serine Threonine Kinase 11 (STK11) through miR-100 in Head and Neck Cancer. Figueroa-González G, Carrillo-Hernández JF, Perez-Rodriguez I, Cantú de León D, Campos-Parra AD, Martínez-Gutiérrez AD, Coronel-Hernández J, García-Castillo V, López-Camarillo C, Peralta-Zaragoza O, Jacobo-Herrera NJ, Guardado-Estrada M, Pérez-Plasencia C. Genes (Basel). 2020 Sep 8; 11(9):1058. https://doi.org/10.3390/genes11091058.
  21. A Reevaluation of Chitosan-Decorated Nanoparticles to Cross the Blood-Brain Barrier. Cortés H, Alcalá-Alcalá S, Caballero-Florán IH, Bernal-Chávez SA, Ávalos-Fuentes A, González-Torres M, González-Del Carmen M, Figueroa- González G, Reyes-Hernández OD, Floran B, Del Prado-Audelo ML, Leyva- Gómez G. Membranes (Basel). 2020 Aug 30; 10(9):212.https://doi.org/10.3390/membranes10090212.
  22. Xanthan gum in drug release. Cortes H, Caballero-Florán IH, Mendoza-Muñoz N, Escutia-Guadarrama L, Figueroa-González G, Reyes-Hernández OD, González- Del Carmen M, Varela-Cardoso M, González-Torres M, Florán B, Del Prado- Audelo ML, Leyva-Gómez G. Cell Mol Biol (Noisy-le-grand). 2020 Jun 25; 66(4):199-207. https://doi.org/10.14715/cmb/2020.66.4.24
  23. Hyaluronic acid in wound dressings. Cortes H, Caballero-Florán IH, Mendoza-Muñoz N, Córdova-Villanueva EN, Escutia-Guadarrama L, Figueroa-González G,Reyes-Hernández OD, González-Del Carmen M, Varela-Cardoso M, Magaña JJ, Florán B, Del Prado-Audelo ML, Leyva-Gómez G. Cell Mol Biol (Noisy-le-grand). 2020 Jun 25; 66(4):191-198. https://doi.org/10.14715/cmb/2020.66.4.23
  24. Non-invasive methods for evaluation of skin manifestations in patients with ichthyosis. Cortés H, Figueroa-González G, Reyes-Hernández OD, Magaña JJ, Leyva-García N, Cariño-Calvo L, González-Del Carmen M, Leyva-Gómez G. Arch Dermatol Res. 2020 May; 312(4):231-236. https://doi.org/10.1007/s00403-019-01987-w. Epub 2019 Oct 17.
  25. Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications. Guadarrama-Acevedo MC, Mendoza-Flores RA, Del Prado-Audelo ML, Urbán-Morlán Z, Giraldo- Gomez DM, Magaña JJ, González-Torres M, Reyes-Hernández OD, Figueroa- González G, Caballero-Florán IH, Florán-Hernández CD, Florán B, Cortés H, Leyva-Gómez G. Pharmaceutics. 2019 Aug 3; 11(8):389. https://doi.org/10.3390/pharmaceutics11080389.
  26. Modifications in Vaginal Microbiota and Their Influence on Drug Release: Challenges and Opportunities. Leyva-Gómez G, Prado-Audelo MLD, Ortega- Peña S, Mendoza-Muñoz N, Urbán-Morlán Z, González-Torres M, González-Del Carmen M, Figueroa-González G, Reyes-Hernández OD, Cortés H. Pharmaceutics. 2019 May 6; 11(5):217.https://doi.org/10.3390/pharmaceutics11050217.
  27. Cell migration and proliferation are regulated by miR-26a in colorectal cancer via the PTEN-AKT axis. Coronel-Hernández J, López-Urrutia E, Contreras-Romero C, Delgado-Waldo I, Figueroa-González G, Campos-Parra AD, Salgado-García R, Martínez-Gutierrez A, Rodríguez-Morales M, Jacobo-Herrera N, Terrazas LI, Silva-Carmona A, López-Camarillo C, Pérez-Plasencia C. Cancer Cell Int. 2019 Apr 2; 19:80. http://dx.doi.org/10.1186/s12935-019-0802-5. eCollection 2019.
  28. Long Non-Coding RNAs as New Master Regulators of Resistance to Systemic Treatments in Breast Cancer. Campos-Parra AD, López-Urrutia E, Orozco Moreno LT, López-Camarillo C, Meza-Menchaca T, Figueroa González G, Bustamante Montes LP, Pérez-Plasencia C. Int J Mol Sci. 2018 Sep 11; 19(9):2711. https://doi.org/10.3390/ijms19092711
  29. Strategies for the evaluation of DNA damage and repair mechanisms in cancer. Figueroa-González G, Pérez-Plasencia C. Oncol Lett. 2017 Jun; 13(6):3982- 3988. https://doi.org/10.3892/ol.2017.6002.Epub 2017 Apr 6.