LÍNEA DE INVESTIGACIÓN EN SÍNTESIS FARMACÉUTICA

RESPONSABLE
Dr. Adelfo Natalio Reyes Ramírez

Prof. de Carrera Titular “B”

Teléfono: 55 5623 0794

LI-FESZ-060506

UBICACIÓN
Laboratorio L-4, Primer nivel de la Unidad Multidisciplinaria de Investigación Experimental Zaragoza. Campus II. FES Zaragoza, UNAM, Ciudad de México, México. CP09230

INTEGRANTES

• Dra. A. Lourdes Castillo Granada
• Q.F.B. Fernando Rivera Sánchez

PRODUCCIÓN CIENTÍFICA

1. Synthesis of novel isoindolone derivatives via cascade reactions.
Contrasting diastereoselectivity under solution-phase vis-a-vis solvent-free
ball-milling reaction conditions. Omar Sánchez-Antonio,a Rodrigo González-
Olvera,b Alejandro Aguilera-Cruz,b Adelfo Reyes-Ramírez,b,* and Eusebio
Juaristi a,c, *Aceptado para su publicación en Tetrahedron.

2. Effect of N-Benzylpiperazine, Its Metabolite N-Benzylethylenediamine, and
Its Disubstituted Analogue N,N’-Dibenzylpiperazine on the Acquisition,
Formation, and Consolidation of Memory in Mice. Juan Carlos Castillo-
Hernández, Josué A. Velázquez-Moyado, Adelfo Reyes-Ramírez, Elena G.
Ramírez-López, Martín González- Andrade, Andrés Navarrete.
Pharmacology. 2017, 99, 268-274. DOI: 10.1159/000457905. ISSN: 0031-
7012 (Print) e- ISSN: 1423-0313 (Online).

3. Synthesis and docking study of chromones, evaluation of their vasorelaxant
effect in rat aorta and screening as phosphodiesterase inhibitors. Fernando
Rodríguez-Ramos, Martín González-Andrade, Andrés Navarrete, Ivonne
Arellano-Jimenez Carlos Alarcón, Alejandro Aguilera-Cruz, and Adelfo
Reyes-Ramírez. Rev Latinoamer Quím. 2015, 43(1), 7-21. [ ISNN: 0370-
5943].

4. Study on Action Mechanism of 1-(4-Methoxy-2-Methylphenyl)Piperazine
(MMPP) in Acquisition, Formation, and Consolidation of Memory in Mice.
Andrés Navarrete, Francisco X. Flores-Machorro, Ruth I. Téllez-Ballesteros,
José Luis Balderas, Adelfo Reyes. Drug Development Research 2014,
75(2), 59-67. DOI: 10.1002/ddr.21094. [Online ISSN: 1098-2299. Impact
Factor: 0.734 (2013)].

5. Synthesis, docking study and relaxant effect of 2-alkyl and 2-naphthyl
chromones on rat aorta and guinea-pig trachea through phosphodiesterase
inhibition. Fernando Rodríguez-Ramos, Andrés Navarrete, Martín González-
Andrade, Carlos Alarcón, Alejandro Aguilera-Cruz, and Adelfo Reyes-
Ramírez.. Bioorganic Chemistry. 2013, 50, 17-25.
doi.org/10.1016/j.bioorg.2013.07.001. [ISSN: 0045-2068 (Print) e- ISSN:
1090-2120 (Online). Impact Factor: 2.951 (2013)].

6. Gastroprotection of Suaveolol, Isolated from Hyptis suaveolens, against
Ethanol-Induced Gastric Lesions in Wistar Rats: Role of Prostaglandins,
Nitric Oxide and Sulfhydryls. Carlos Vera-Arzave, Leticia Cruz Antonio,
Jesús Arrieta, Gerardo Cruz-Hernández, Antonio Magdiel Velázquez-
Méndez, Adelfo Reyes-Ramírez and María Elena Sánchez-Mendoza.
Molecules 2012, 17(8), 8917-8927. doi:10.3390/molecules17088917. [ISSN:
420-3049. Impact Factor: 2.095 (2013)].

7. Synthesis, biological evaluation, and docking studies of gigantol analogs as
calmodulin inhibitors. Adelfo Reyes-Ramírez, Martha Leyte-Lugo, Mario
Figueroa, Trinidad Serrano-Alba, Martín González-Andrade and Rachel
Mata. European Journal of Medicinal Chemistry. 2011, 46, 2699-2708.
doi:10.1016/j.ejmech.2011.03.057. [ISSN: 0223-5234. Impact Factor: 3.432
(2013)].

8. Carbenoxolone gastroprotective mechanism: participation of nitric oxidecGMP-
KATP pathway in ethanol-induced gastric injury in the rat. Aracely
Chávez Piña, Gabriela Tapia Álvarez, Adelfo Reyes, Andrés Navarrete.
Fundamental & Clinical Pharmacology. 2011, 25(6), 717-722. doi:
10.1111/j.1472-8206.2010.00897.x. Online [ISSN: 1472-8206. Impact
Factor: 2.08 (2013)].

9. Bioassay-guided Isolation of an Anti-Ulcer Compound, Tagitinin C, from
Tithonia diversifolia: Role of Nitric Oxide, Prostaglandins and Sulfhydryls.
María Elena Sánchez-Mendoza, Adelfo Reyes-Ramírez, Leticia Cruz
Antonio, Luis Martínez Jiménez, Juan Rodríguez-Silverio and Jesús Arrieta.
Molecules. 2011, 16, 665-674. doi:10.3390/molecules16010665. [ISSN:
420-3049. Impact Factor: 2.095 (2013)].

10.Synthesis and Nootropic Activity of Some 2,3-Dihydro-1H-isoindol-1-one
Derivatives Structurally Related with Piracetam. Adelfo Reyes, Leticia
Huerta, Marisol Alfaro and Andrés Navarrete. Chemistry & Biodiversity.
2010, 7, 2718-2726. [ISSN: 1612-1872 (Print), 1612-1880 (Electronic).
Impact Factor: 1.795 (2013/2014)].

11.Palmitone prevents pentylenetetrazole-caused neuronal damage in the CA3
hippocampal region of prepubertal rats. E Cano-Europa, Ma Eva González-
Trujano, Adelfo Reyes-Ramírez, A Hernández-García, V Blas-Valdivia, R
Ortiz-Butrón. Neurosci Lett. 2010, 470, 111-114. [ISSN: 0304-3940. Impact
Factor: 2.055 (2013)].

12.Effect of repeated administration of Annona Diversifolia saff. (ilama) extracts
and palmitone on rat amygdala kindling. Ma Eva González-Trujano, Leonor
López-Meraz, Adelfo Reyes-Ramírez, Miguel Aguillón, Adrián Martínez.
Epilepsy & behavior: E&B. 2009, 16(4), 590-595. [ISSN: 1525-5050 (Print)
1525-5069 (Electronic). Impact Factor: 2.061 (2013/2014)].

13.Papel de los grupos sulfhidrilos, las prostaglandinas y el óxido nítrico
endógeno, en la gastroprotección del lanosterol sobre las lesiones gástricas
inducidas por etanol en rata. Roles of sulfhydryls, prostaglandins and
endogenous nitric oxide, in gastroprotection by lanosterol on etanol-induced
gastric mucosal lesions in rats. Jesús Arrieta, Benito Reyes-Trejo, Adelfo
Reyes-Ramírez, Juan Rodríguez-Silverio, María Elena Sánchez-Mendoza.
Rev. Mexicana de Ciencias Farmacéuticas. 2009, 40(3), 17-21. [ISSN 1870-
0195].

14.Antinociceptive and anti-Inflammatory effects of compounds isolated from
Scaphyglottis livida and Maxillaria densa. Myrna Déciga-Campos, Juan
Francisco Palacios-Espinos, Adelfo Reyes-Ramírez, Rachel Mata. Journal
of Ethnopharmacology. 2007, 114, 161-168. [ISSN: 0378-8741. Impact
Factor: 2.939 (2013)].

15.Anticonvulsant Effect of Annona Diversifolia Saff. and Palmitone on
Penicillin-induced Convulsive Activity. A Behavioral and EEG Study in Rats.
Ma. Eva González-Trujano, Adelfo Reyes-Ramírez, Andrés Navarrete.
Epilepsia. 2006, 47(11), 1810-1817. [Online ISSN: 1528-1167. Impact
Factor: 4.584 (2013)].

16.Palmitone Isolated from Annona diversifolia Induces an Anxiolytic-Like
Effect in Mice. Ma. Eva González-Trujano, Ana Laura Martínez, Adelfo
Reyes-Ramírez, Benito Reyes-Trejo, Andrés Navarrete. Planta Médica.
2006, 72(8), 703-707. [ISSN: 0032-0943. Impact Factor: 2.339 (2013)].

17.Phytotoxins from Hofmeisteria Schaffneri: Isolation and Synthesis of 2’-(2’’-
Hydroxy-4’’-methylphenyl)-2’-oxoethyl Acetate. Araceli Pérez-Vásquez,
Adelfo Reyes, Edelmira Linares, Robert Bye, Rachel Mata. J. Nat. Prod.
2005, 68, 959-962. [ISSN: 0974-5211. Impact Factor: 1.265 (2013)].

18.Stereoselective alkylation of C2-symmetric chiral N-phthaloyl-glycinamides in
the preparation of enantiopure -amino acids. Adelfo Reyes y Eusebio
Juaristi. Tetrahedron: Asymmetry. 2000, 11, 1411-1423. [ISSN: 0957-4166.
Impact Factor: 2.165 (2013)].

19.Stereoselective Tandem Michael-Intramolecular Cyclization Approach to
Functionalized Pyrroloisoindolones. Adelfo Reyes, Ignacio Regla, Mabel C.
Fragoso, Laura A. Vallejo, Patricia Demare, Hugo A. Jiménez-Vázquez,
Yara Ramírez, Eusebio Juaristi y Joaquín Tamariz. Tetrahedron. 1999, 55,
11187-11202. [ISSN: 0040-4020. Impact Factor: 2.817 (2013)].

20.Recent applications of -phenylethylamine (-PEA) in the preparation of
enantiopure compounds. Part 3: -PEA as chiral auxiliary. Part 4: -PEA as
chiral reagent in the stereodifferentiation of prochiral substrates. Eusebio
Juaristi, José Luis León-Romo, Adelfo Reyes, Jaime Escalante.
Tetrahedron: Asymmetry. 1999, 10, 2441-2495. [ISSN: 0957-4166. Impact
Factor: 2.165 (2013)].

21.Recent applications of -phenylethylamine (-PEA) in the preparation of
enantiopure compounds. Part 1: Incorporation in chiral catalysts. Part 2: -
PEA and derivatives as resolving agents. Eusebio Juaristi, Jaime Escalante,
José Luis León-Romo, Adelfo Reyes. Tetrahedron: Asymmetry. 1998, 9,
715-740. [ISSN: 0957-4166. Impact Factor: 2.165 (2013)].

22.Convenient Route for the Preparation of C2-Symmetric (+)-(2R,3R)- and (-)-
(2S,3S)-2,3-Diphenylaziridine. Adelfo Reyes, Eusebio Juaristi. Chirality.
1998, 10, 95-99. [Online ISSN: 1520-636X. Impact Factor: 1.724 (2013)].

23.Novel Applications of Raney Nickel/Isopropanol: Efficient System for the
Reduction of Organic Compounds. Ignacio Regla, Adelfo Reyes, Claudia
Körber, Patricia Demare, Osvaldo Estrada, Eusebio Juaristi. Synthetic
Communications. 1997, 27(5), 817-823. [ISSN: 0039-7911 (Print), 532-2432
(Online). Impact Factor: 0.984 (2013)].

24.Use of (S)--Methylbenzylamine in the Resolution of Racemic 2-Octanol
and -Methylbenzyl Alcohol. Adelfo Reyes, Eusebio Juaristi. Synthetic
Communications. 1995, 25(7),1053-1058. [ISSN: 0039-7911 (Print), 532-
2432 (Online). Impact Factor: 0.984 (2013)].

1. Solicitud de patente IMPI: MX/a/2018/005359. Folio: MX/E/2018/029522. 27 de abril de 2018
Ha sido acreedor de distinciones como: Miembro del Comité de Expertos en Nomenclatura y Terminología de la Comisión Permanente de la Farmacopea de los Estados Unidos Mexicanos. 2004 a la fecha. PRIDE Nivel C. 1995 a la fecha. Miembro del Sistema Nacional de Investigadores como Candidato de 1996 -1998 y en el Nivel 1 de 1999-2019. Cátedra Especial Jesús Romo Armería (CTIC) 2012 – 2013.